Developing Tomorrow’s Treatments
Anaveon’s mission is to transform cytokines into life-saving treatments. The Company was founded in 2017 by experts in cutting-edge immunology, who wanted to design and develop patient treatments that benefit society.
This remains our vision today. Anaveon is a biopharmaceutical company that specializes in developing novel treatments for diseases with high unmet needs. The team has the skills to make this vision a reality: we are committed to transforming immunological insights into life-saving therapies.
Others share our vision, and investors have backed Anaveon with funding of more than 36 million CHF (€34 million).
Since 2017, Anaveon has grown in size and strength.
The first drug we are taking into clinical trials is
ANV419 – a selective
Company Information Pack
Read about Anaveon’s work towards our mission to transform cytokines into life-saving treatments. In this downloadable info package, you can find out more about the company, our team of dedicated experts, the drugs we are preparing to take into clinical trials, and the programs we have in the pipeline.
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To ask us a question, or find out about collaboration opportunities, email us at firstname.lastname@example.org.
Anaveon®’s pipeline based on engineered cytokines
Anaveon is exploiting the power of cytokines to orchestrate immune responses through safe and effective treatments for a variety of serious diseases. Our pipeline reflects this: we are developing
a unique no-alpha
- ANV 419 Systemic no-alpha IL-2
- ANV600 Target no-alpha IL-2
- Engineered Cytokine
The programs in Anaveon’s pipeline have potential across a range of therapeutic areas.
Cytokine immunotherapies could be used to treat solid tumors, including melanoma, renal cell cancer and bladder cancer.
Cancers of the blood, bone marrow and lymph nodes are potential targets, including leukemia, lymphoma and myeloma.
The programs in Anaveon’s pipeline could be used in combination with checkpoint inhibitors, innate immunity agonists, targeted agents or depleting antibodies.
In combination with cutting-edge cell therapies, Anaveon’s programs could offer new benefits for cancer patients.
- ANV419 is a fusion protein of
IL-2with an anti-IL-2 antibody
- In vitro and in vivo, ANV419 selectively signals through the IL-2Rβ/γ and promotes the expansion of both NK and CD8+ T cells but not Tregs
- ANV419 is currently in first human studies to determine the optimal dose for safety and efficacy
- Development in multiple cancer indications are planned to be initiated in 2022
ANV419 has already displayed exceptional safety in early clinical studies and non-human primates. It is selective by design: ANV419 only promotes the function of CD8+ T cells and NK cells as immune effector cells while sparing regulatory T cells. Therefore, it is a potential treatment for a range of cancer types.
ANV419 is a novel CD122 selective IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T cell and NK cell stimulatory function in vitro and in vivo
SITC Annual Meeting. 2020 Nov 9-14
Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human Interleukin-2
Sci Transl Med. 2016 Nov 30;8(367):367ra166.
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
Immunity. 2015 May 19;42(5):815-25